Abstract: With the end of the United States NIH budget doubling and completion of the Human Genome Project, there is a need to translate genome-era discoveries into clinical utility. The difficulties in making bench-to-bedside translations have been well described. The nascent field of translational bioinformatics may help. Dr. Butte’s lab at Stanford builds and applies tools that convert more than a trillion points of molecular, clinical, and epidemiological data – measured by researchers and clinicians over the past decade – into diagnostics, therapeutics, and new insights into disease. Dr. Butte, a bioinformatician and pediatric endocrinologist, will highlight his lab’s work on using publicly-available molecular measurements to find new uses for drugs, relating genes and environment to disease, and evaluating patients presenting with whole genomes sequenced.